Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells.

Abstract

Adhesion of rat glomerular epithelial cells (GEC) to collagen activates focal adhesion kinase (FAK) and the Ras-extracellular signal-regulated kinase (ERK) pathway and supports survival (prevents apoptosis). The present study addresses the relationship between actin organization and the survival phenotype. Parental GEC (adherent to collagen) and GEC stably… (More)

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@article{Bijian2005ActinCR, title={Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells.}, author={Krikor Bijian and Tomoko Y. Takano and Joan Papillon and Ludmilla Le Berre and Jean-Louis R Michaud and Christopher R. J. Kennedy and Andrey V Cybulsky}, journal={American journal of physiology. Renal physiology}, year={2005}, volume={289 6}, pages={F1313-23} }