Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

  title={Actin cap associated focal adhesions and their distinct role in cellular mechanosensing},
  author={Dong-Hwee Kim and Shyam B. Khatau and Yunfeng Feng and Sam Walcott and Sean X. Sun and Gregory D. Longmore and Denis Wirtz},
  booktitle={Scientific reports},
The ability for cells to sense and adapt to different physical microenvironments plays a critical role in development, immune responses, and cancer metastasis. Here we identify a small subset of focal adhesions that terminate fibers in the actin cap, a highly ordered filamentous actin structure that is anchored to the top of the nucleus by the LINC complexes; these differ from conventional focal adhesions in morphology, subcellular organization, movements, turnover dynamics, and response to… CONTINUE READING
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