Actin-binding proteins required for reliable chromosome segregation in mitosis.

@article{Gerisch2004ActinbindingPR,
  title={Actin-binding proteins required for reliable chromosome segregation in mitosis.},
  author={G{\"u}nther Gerisch and Jan Faix and Jana Koehler and Annette Mueller-Taubenberger},
  journal={Cell motility and the cytoskeleton},
  year={2004},
  volume={57 1},
  pages={18-25}
}
While studying mitosis in Dictyostelium mutants with deficiencies in actin-binding proteins, we found that two of these proteins, cortexillin and Aip1, are required for the precise segregation of chromosomes. Atypical spindles and nuclei with varying DNA content indicate that mutants lacking cortexillin or Aip1 are genetically unstable. These aberrations… CONTINUE READING