Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos.

  title={Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos.},
  author={Christine M Field and Martin W{\"u}hr and Graham A. Anderson and Hao Yuan Kueh and Devin Strickland and Timothy J Mitchison},
  journal={Journal of cell science},
  volume={124 Pt 12},
The mechanical properties of cells change as they proceed through the cell cycle, primarily owing to regulation of actin and myosin II. Most models for cell mechanics focus on actomyosin in the cortex and ignore possible roles in bulk cytoplasm. We explored cell cycle regulation of bulk cytoplasmic actomyosin in Xenopus egg extracts, which is almost undiluted cytoplasm from unfertilized eggs. We observed dramatic gelation-contraction of actomyosin in mitotic (M phase) extract where Cdk1… CONTINUE READING


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