Actin-based motility drives baculovirus transit to the nucleus and cell surface

@inproceedings{Ohkawa2010ActinbasedMD,
  title={Actin-based motility drives baculovirus transit to the nucleus and cell surface},
  author={Taro Ohkawa and Loy E. Volkman and Matthew D Welch},
  booktitle={The Journal of cell biology},
  year={2010}
}
Most viruses move intracellularly to and from their sites of replication using microtubule-based mechanisms. In this study, we show that nucleocapsids of the baculovirus Autographa californica multiple nucleopolyhedrovirus undergo intracellular motility driven by actin polymerization. Motility requires the viral P78/83 capsid protein and the host Arp2/3 complex. Surprisingly, the virus directs two sequential and coordinated phases of actin-based motility. Immediately after cell entry, motility… CONTINUE READING

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