Actin as target for modification by bacterial protein toxins

@article{Aktories2011ActinAT,
  title={Actin as target for modification by bacterial protein toxins},
  author={K. Aktories and A. Lang and Carsten Schwan and H. Mannherz},
  journal={The FEBS Journal},
  year={2011},
  volume={278}
}
  • K. Aktories, A. Lang, +1 author H. Mannherz
  • Published 2011
  • Medicine, Biology
  • The FEBS Journal
  • Various bacterial protein toxins and effectors target the actin cytoskeleton. At least three groups of toxins/effectors can be identified, which directly modify actin molecules. One group of toxins/effectors causes ADP‐ribosylation of actin at arginine‐177, thereby inhibiting actin polymerization. Members of this group are numerous binary actin–ADP‐ribosylating exotoxins (e.g. Clostridium botulinum C2 toxin) as well as several bacterial ADP‐ribosyltransferases (e.g. Salmonella enterica SpvB… CONTINUE READING
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