Actin as target for modification by bacterial protein toxins.

  title={Actin as target for modification by bacterial protein toxins.},
  author={Klaus Aktories and Alexander E. Lang and Carsten Schwan and Hans Georg Mannherz},
  journal={The FEBS journal},
  volume={278 23},
Various bacterial protein toxins and effectors target the actin cytoskeleton. At least three groups of toxins/effectors can be identified, which directly modify actin molecules. One group of toxins/effectors causes ADP-ribosylation of actin at arginine-177, thereby inhibiting actin polymerization. Members of this group are numerous binary actin-ADP-ribosylating exotoxins (e.g. Clostridium botulinum C2 toxin) as well as several bacterial ADP-ribosyltransferases (e.g. Salmonella enterica SpvB… CONTINUE READING
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