Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.

@article{Jerdeva2005ActinAN,
  title={Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.},
  author={Galina V. Jerdeva and Kaijin Wu and Francie A. Yarber and Christopher J Rhodes and Daniel Kalman and Joel E. Schechter and Sarah F Hamm-Alvarez},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 20},
  pages={
          4797-812
        }
}
The acinar epithelial cells of the lacrimal gland exocytose the contents of mature secretory vesicles containing tear proteins at their apical membranes in response to secretagogues. Here we use time-lapse confocal fluorescence microscopy and fluorescence recovery after photobleaching to investigate the changes in actin filaments located beneath the apical membrane during exocytosis evoked by the muscarinic agonist, carbachol (100 microM). Time-lapse confocal fluorescence microscopy of apical… CONTINUE READING

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