Actin and microtubules in neurite initiation: are MAPs the missing link?

@article{Dehmelt2004ActinAM,
  title={Actin and microtubules in neurite initiation: are MAPs the missing link?},
  author={Leif Dehmelt and Shelley Halpain},
  journal={Journal of neurobiology},
  year={2004},
  volume={58 1},
  pages={18-33}
}
During neurite initiation microtubules align to form a tight bundle and actin filaments reorganize to produce a growth cone. The mechanisms that underlie these highly coordinated cytoskeletal rearrangements are not yet fully understood. Recently, various levels of coordination between the actin- and microtubule-based cytoskeletons have been observed during cellular migration and morphogenesis, processes that share some similarities to neurite initiation. Direct, physical association between… CONTINUE READING
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