Actin and PIP3 waves in giant cells reveal the inherent length scale of an excited state.

@article{Gerhardt2014ActinAP,
  title={Actin and PIP3 waves in giant cells reveal the inherent length scale of an excited state.},
  author={Matthias Gerhardt and Mary Ecke and Michael Walz and Andreas Stengl and Carsten Beta and G{\"u}nther Gerisch},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 20},
  pages={4507-17}
}
The membrane and actin cortex of a motile cell can autonomously differentiate into two states, one typical of the front, the other of the tail. On the substrate-attached surface of Dictyostelium discoideum cells, dynamic patterns of front-like and tail-like states are generated that are well suited to monitor transitions between these states. To image large-scale pattern dynamics independently of boundary effects, we produced giant cells by electric-pulse-induced cell fusion. In these cells… CONTINUE READING

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