Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL

@article{Miralles2003ActinDC,
  title={Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL},
  author={F. Miralles and G. Posern and A. Zaromytidou and R. Treisman},
  journal={Cell},
  year={2003},
  volume={113},
  pages={329-342}
}
Rho GTPases regulate the transcription factor SRF via their ability to induce actin polymerization. SRF activity responds to G actin, but the mechanism of this has remained unclear. We show that Rho-actin signaling regulates the subcellular localization of the myocardin-related SRF coactivator MAL, rearranged in t(1;22)(p13;q13) AML. The MAL-SRF interaction displays the predicted properties of a Rho-regulated SRF cofactor. MAL is predominantly cytoplasmic in serum-starved cells, but accumulates… Expand
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