Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL

@article{Miralles2003ActinDC,
  title={Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL},
  author={Francesc Miralles and Guido Posern and A. Zaromytidou and Richard Treisman},
  journal={Cell},
  year={2003},
  volume={113},
  pages={329-342}
}

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The findings suggest a role of actin-MAL-SRF signaling in cell motility and that MAL is implicated in antimigratory responses through upregulation of the cytoskeleton-associated proteins Integrin α5, PKP2 and FHL1 in non-invasive cells.

Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways

It is proposed that the interaction between mDia1 and POPX2 (PPM1F) serves to regulate both the actin cytoskeleton and SRF-mediated transcription, and to link the CDC42/RAC1 pathways with those of RhoA.

RASSF1A is required for the maintenance of nuclear actin levels

It is demonstrated that endogenous RASSF1A localises to the nuclear envelope (NE) and is required for nucleo-cytoplasmic actin transport and the concomitant regulation of Myocardin-related transcription factor A (MRTF-A), a coactivator of the transcription factor serum response factor (SRF).
...

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