Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury.

@article{Xiong1999ActeosideIA,
  title={Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury.},
  author={Qing-feng Xiong and Koji Hase and Yasuhiro Tezuka and Takashi Namba and Shigetoshi Kadota},
  journal={Life sciences},
  year={1999},
  volume={65 4},
  pages={421-30}
}
We assessed the effect of acteoside, a naturally occurring antioxidative phenylethanoid, on hepatic apoptosis and the subsequent liver failure induced by D-Galactosamine (D-GalN) and lipopolysaccharide (LPS). A co-administration of D-GalN (700 mg/kg) and LPS (35 microg/kg) to mice evoked typical hepatic apoptosis characterized by DNA fragmentation and apoptotic body formation, resulting in fulminant hepatitis and lethality of mice. Pre-administration of acteoside at 10 or 50 mg/kg… CONTINUE READING
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