Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

Abstract

Interleukin-17 (IL-17), a proinflammatory cytokine mainly produced by cells of the T helper 17 (T(H)17) lineage, is required for host defense against bacterial and fungal infections and plays a critical role in the pathogenesis of inflammatory and autoimmune diseases. Act1 is an essential adaptor molecule in IL-17-mediated signaling and is recruited to the… (More)
DOI: 10.1126/scisignal.2000382

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