Acrylonitrile-induced gastrointestinal hemorrhage and the effects of metabolism modulation in rats.


Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with phenobarbital decreased the VCN-induced… (More)


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