Acrylamide-induced neurotoxicity in primary astrocytes and microglia: Roles of the Nrf2-ARE and NF-κB pathways.

@article{Zhao2017AcrylamideinducedNI,
  title={Acrylamide-induced neurotoxicity in primary astrocytes and microglia: Roles of the Nrf2-ARE and NF-κB pathways.},
  author={Mengyao Zhao and Fu Sheng Lewis Wang and Xiaosong Hu and Fang Chen and Hing M. Chan},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2017},
  volume={106 Pt A},
  pages={25-35}
}
Acrylamide (AA) is a common food contaminant formed during food heat processing that has neurotoxic effects. We hypothesize that AA induces oxidative stress in astrocytes and microglia, leading to neurotoxicity. Oxidative status, translocation of Nrf2 and NF-κB, and related down-stream targets were measured in primary astrocytes and microglia obtained from BALB/c mice. The results showed that AA increased reactive oxygen species (ROS) formation and reduced glutathione levels, causing successive… CONTINUE READING
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