Acrylamide binding to the DNA and protamine of spermiogenic stages in the mouse and its relationship to genetic damage.

@article{Sega1989AcrylamideBT,
  title={Acrylamide binding to the DNA and protamine of spermiogenic stages in the mouse and its relationship to genetic damage.},
  author={Gary A. Sega and R P Alcota and C P Tancongco and P A Brimer},
  journal={Mutation research},
  year={1989},
  volume={216 4},
  pages={221-30}
}
Mice received an intraperitoneal injection of 14C-labeled acrylamide (AA) at an exposure of 125 mg/kg to equal that used in genetic studies carried out by Shelby et al. (1986). Subsequently, spermatozoa were recovered from the reproductive tracts of the animals over a 3-week period and assayed for the amount of bound AA. A strong increase in the level of binding occurred in late-spermatid to early-spermatozoa stages; these same stages are also genetically most sensitive to the action of AA. At… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Toxicological Review of Acrylamide

2007
View 8 Excerpts
Highly Influenced

Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide.

Toxicological sciences : an official journal of the Society of Toxicology • 2009
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…