Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies.

@article{Hartley1997AcrylamideA2,
  title={Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies.},
  author={Christine Hartley and Valerie E Anderson and Brian H. Anderton and Jennifer France Robertson},
  journal={Neuropathology and applied neurobiology},
  year={1997},
  volume={23 5},
  pages={364-72}
}
Neurofilament accumulations are characteristic of a number of neurological conditions including amyotrophic lateral sclerosis, giant axonal neuropathies and several chemically-induced neuropathies. Although the mechanism(s) leading to neurofilament accumulation are unknown, it is possible that similar processes occur both in disease and in chemically… CONTINUE READING