Acrosome reaction induced by immunoaggregation of a proteinase inhibitor bound to the murine sperm head.

@article{Aarons1991AcrosomeRI,
  title={Acrosome reaction induced by immunoaggregation of a proteinase inhibitor bound to the murine sperm head.},
  author={D H Aarons and Holly Boettger-Tong and Geoffrey Holt and Gary R. Poirier},
  journal={Molecular reproduction and development},
  year={1991},
  volume={30 3},
  pages={258-64}
}
ZP3, a glycoprotein of the murine zona pellucida, functions both to bind acrosome intact sperm and to induce the acrosome reaction. Solubilized whole zonae as well as purified ZP3 are able to induce acrosome reactions in capacitated sperm. Pronase digests of whole zonae yield glycopeptides that bind to sperm but are unable to induce acrosome reactions. However, immunoaggregation of these glycopeptides results in the exocytosis of the acrosome in the majority of treated sperm. The data suggest… CONTINUE READING
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