Acronycine epoxide: a new acridone alkaloid from several Sarcomelicope species.

  title={Acronycine epoxide: a new acridone alkaloid from several Sarcomelicope species.},
  author={M. Brum-Bousquet and S. Mitaku and A. Skaltsounis and F. Tillequin and M. Koch},
  journal={Planta medica},
  volume={54 5},
Sarcomelicope alkaloids as leads for the discovery of new antitumor acronycine derivatives
The acridone alkaloid acronycine first isolated from Acronychiabaueri Schott (Rutaceae) in 1948, was later shown to exhibit a promising activity against a broad spectrum of solid tumors.Expand
Acridone Alkaloids.
  • J. Michael
  • Medicine, Biology
  • The Alkaloids. Chemistry and biology
  • 2017
Syntheses of acridone alkaloids and certain analogs reported during the review period are comprehensively covered, including cytotoxicity and anticancer activity, antimicrobial and antiparasitic properties, and enzyme inhibition. Expand
Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts
The aim of this review is to highlight the variety of established protein recognition of DNA adducts to particularly focus on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) function in DNAAdduct interaction with illustration using original experiments performed with S23906-1/DNA adduct. Expand
Cytotoxic turrianes from Kermadecia elliptica: Hemisynthesis and biological activities of kermadecin A derivatives
Kermadecin A is a cytotoxic natural macrocycle, containing a bisresorcinol and a pyran ring. A series of derivatives has been synthesized from the natural product in order to investigate the role ofExpand
Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.
Racemic diacetate 21 showed a strong activity against KB-3-1 cell lines and was selected for in vivo evaluation and proved to be active, inhibiting tumor growth by more than 80%. Expand
Design, synthesis and anticancer activity of novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives.
On the basis of the chemical structures of psorospermin with a xanthone template and acronycine derivatives with an acridone template, rac-1 and rac-2 constructed on anExpand
Synthesis of new tetracyclic 7-oxo-pyrido[3,2,1-de]acridine derivatives
Abstract A series of (±)3-hydroxyl- and 2,3-dihydroxy-2,3-dihydro-7-oxopyrido[3,2,1- de ]acridines were synthesized for antitumor evaluation. These agents can be considered as analogues of glyfolineExpand
Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-125H-one series.
The oxirane alkylating unit appears indispensible to observe significant antiproliferative activity in both series, but the presence of the angularly fused furan ring does not appear as a crucial structural requirement to observesignificant cytotoxic activity. Expand
Influence of the Stereoisomeric Position of the Reactive Acetate Groups of the Benzo[b]Acronycine derivative S23906-1 on Its DNA Alkylation, Helix-Opening, Cytotoxic, and Antitumor Activities
It was shown that the S and R orientations of the acetate on C1 asymmetric carbon lead to different local opening of the DNA, as visualized using nuclease S1 mapping, which could lead to modulated DNA-repair, protein/DNA interaction, and apoptosis processes. Expand
Structure-activity relationships in the acronycine and benzo[b]acronycine series: role of the pyran ring.
The presence of the angularly fused dimethylpyran ring appears as an indispensable structural requirement to observe significant cytotoxic activity in this series of acronycine compounds. Expand