Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications.

@article{Renehan2003AcromegalyAC,
  title={Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications.},
  author={Andrew G Renehan and Jean O'Connell and D P O'halloran and Fergus Shanahan and Christopher S. Potten and Sarah T O'dwyer and Stephen M. Shalet},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2003},
  volume={35 11-12},
  pages={
          712-25
        }
}
Acromegaly is an endocrine disorder characterised by sustained hypersecretion of growth hormone (GH) with concomitant elevation of insulin-like growth factor (IGF)-I, and is associated with malignancy and premature mortality from cardiovascular and respiratory diseases. In particular, there may be an increased risk of colorectal neoplasia, but the exact extent of this is contentious. Colonoscopy-based studies of adenoma prevalence rates in acromegalic patients are misleading, but population… CONTINUE READING
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