Acrolein-mediated injury in nervous system trauma and diseases.

  title={Acrolein-mediated injury in nervous system trauma and diseases.},
  author={Riyi Shi and Todd Rickett and Wenjing Sun},
  journal={Molecular nutrition & food research},
  volume={55 9},
Acrolein, an α,β-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation. This compound is hundreds of times more reactive than other aldehydes such as 4-hydroxynonenal, is produced at much higher concentrations, and persists in solution for much longer than better known free radicals. It has been implicated in disease states known to involve chronic oxidative stress, particularly spinal cord injury and multiple sclerosis. Acrolein may… CONTINUE READING


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