Acrolein induces selective protein carbonylation in synaptosomes.

  title={Acrolein induces selective protein carbonylation in synaptosomes.},
  author={Carlos F. de Mello and Rukhsana Sultana and Marta Piroddi and Jain Cai and William M. Pierce and Jon B. Klein and David Butterfield},
  volume={147 3},
Acrolein, the most reactive of the alpha,beta-unsaturated aldehydes, is endogenously produced by lipid peroxidation, and has been found increased in the brain of patients with Alzheimer's disease. Although it is known that acrolein increases total protein carbonylation and impairs the function of selected proteins, no study has addressed which proteins are selectively carbonylated by this aldehyde. In this study we investigated the effect of increasing concentrations of acrolein (0, 0.005, 0.05… CONTINUE READING
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