Acrolein induces myelin damage in mammalian spinal cord.

  title={Acrolein induces myelin damage in mammalian spinal cord.},
  author={Yunzhou Shi and Wenjing Sun and Jennifer J McBride and Ji Xin Cheng and Riyi Shi},
  journal={Journal of neurochemistry},
  volume={117 3},
Myelin damage can lead to the loss of axonal conduction and paralysis in multiple sclerosis and spinal cord injury. Here, we show that acrolein, a lipid peroxidation product, can cause significant myelin damage in isolated guinea pig spinal cord segments. Acrolein-mediated myelin damage is particularly conspicuous in the paranodal region in both a calcium dependent (nodal lengthening) and a calcium-independent manner (paranodal myelin splitting). In addition, paranodal protein complexes can… CONTINUE READING