Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid.

@article{Nardini2002AcroleininducedCI,
  title={Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid.},
  author={Mirella Nardini and Erik I. Finkelstein and Shanti Reddy and Giuseppe Valacchi and M. Traber and Carroll E. Cross and Albert van der Vliet},
  journal={Toxicology},
  year={2002},
  volume={170 3},
  pages={
          173-85
        }
}
Acrolein is a highly reactive unsaturated hazardous air pollutant of human health concern, particularly as a component of cigarette smoke. In this study, the mechanisms of acrolein-induced cytotoxicity in human bronchial epithelial cells (HBE1) and the modulating effects of antioxidants were examined. Our results show that acrolein induces a cell death pathway in human bronchial epithelial cells, which retain key features of apoptosis, as indicated by phosphatidylserine (PS) externalization and… CONTINUE READING
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