Acrolein-induced cell death in human alveolar macrophages.

  title={Acrolein-induced cell death in human alveolar macrophages.},
  author={Lan Li and Raymond F. Hamilton and David E. Taylor and Andrij Holian},
  journal={Toxicology and applied pharmacology},
  volume={145 2},
Acrolein is an environmental air pollutant that is known to suppress respiratory host defense against infections. The mechanism of the decrease in host defense is not yet clear. In this study, the effects of acrolein on human alveolar macrophages and their function were examined. Acrolein caused dose-dependent cytotoxicity to alveolar macrophages as demonstrated by the induction of apoptosis and necrosis. In addition, at lower doses, acrolein caused induction of heme oxygenase 1 protein… CONTINUE READING