Acrolein genotoxicity in Drosophila melanogaster. III. Effects of metabolism modification.

@article{Barros1994AcroleinGI,
  title={Acrolein genotoxicity in Drosophila melanogaster. III. Effects of metabolism modification.},
  author={Ana Isabel Rivas Barros and Luisa Maria Sierra and M. A. Comendador},
  journal={Mutation research},
  year={1994},
  volume={321 3},
  pages={
          119-26
        }
}
In order to investigate the role of metabolism in acrolein genotoxicity in D. melanogaster, the action of several metabolism modifiers, namely phenobarbital, an inducer of xenobiotic metabolism, phenylimidazole and iproniazid, inhibitors of oxidative activities of cytochrome P450, and diethyl maleate, a glutathione-depleting agent, have been assayed using the sex-linked recessive lethal (SLRL) test, with two different administration routes (feeding and injection). The results support the… CONTINUE READING
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The molecular effects of acrolein.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2000
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