Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease.

  title={Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease.},
  author={Nadia Moretto and Giorgia Volpi and Fiorella Pastore and Fabrizio Facchinetti},
  journal={Annals of the New York Academy of Sciences},
Acrolein (2-propenal) is a highly reactive α,β-unsaturated aldehyde and a respiratory irritant that is ubiquitously present in the environment but that can also be generated endogenously at sites of inflammation. Acrolein is abundant in tobacco smoke, which is the major environmental risk factor for chronic obstructive pulmonary disease (COPD), and elevated levels of acrolein are found in the lung fluids of COPD patients. Its high electrophilicity makes acrolein notorious for its facile… CONTINUE READING
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