Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress.

@article{Mohammad2012AcroleinCI,
  title={Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress.},
  author={Mohammad Khalid Mohammad and Diana Isabel Villacorta Avila and Jingwen Zhang and Shirish Barve and Gavin E. Arteel and Craig J. McClain and Swati Joshi-Barve},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={265 1},
  pages={
          73-82
        }
}
Acrolein is a common environmental, food and water pollutant and a major component of cigarette smoke. Also, it is produced endogenously via lipid peroxidation and cellular metabolism of certain amino acids and drugs. Acrolein is cytotoxic to many cell types including hepatocytes; however the mechanisms are not fully understood. We examined the molecular mechanisms underlying acrolein hepatotoxicity in primary human hepatocytes and hepatoma cells. Acrolein, at pathophysiological concentrations… CONTINUE READING
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