Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults

@article{Lorenz2021AcroleinAO,
  title={Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults},
  author={David R. Lorenz and Vikas Misra and Sukrutha Chettimada and Hajime Uno and Lanqing Wang and Benjamin C. Blount and V{\'i}ctor R. De Jes{\'u}s and Benjamin B. Gelman and Susan Morgello and Steven Wolinsky and Dana Gabuzda},
  journal={EClinicalMedicine},
  year={2021},
  volume={31}
}

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References

SHOWING 1-10 OF 55 REFERENCES
Urinary concentrations of PAH and VOC metabolites in marijuana users.
Urinary Biomarkers of Carcinogenic Exposure among Cigarette, Waterpipe, and Smokeless Tobacco Users and Never Users of Tobacco in the Golestan Cohort Study
TLDR
Environmental exposure from nontobacco sources appeared to contribute to the presence of high levels of PAH metabolites in the Golestan Cohort, and these biomarkers would be useful for exposure assessment in a longitudinal study.
Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005–2006
TLDR
Tobacco smoke was a significant predictor of acrolein exposure in the U.S. population and serum cotinine was asignificant positive predictor of both 3HPMA and CEMA among tobacco smokers.
Characterization of Volatile Organic Compound (VOC) metabolites in Cigarette smokers, Electronic Nicotine Device Users, Dual Users and Non- users of tobacco.
TLDR
While sole ENDs use may be associated with lower VOC exposure compared to cigarette smoking, further study is required to determine the potential health effects of the higher levels of certain reactive aldehydes in ENDS users compared with non-users of tobacco.
Nicotine and Toxicant Exposure among Concurrent Users ("Co-users") of Tobacco and Cannabis.
TLDR
Assessing tobacco and cannabis use in tandem will allow for more precise measurement of outcomes related to one or both substances, and can provide additional information on potential health effects related to co-use.
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein
TLDR
The data indicate that CEMA, the biomarker of acrylonitrile exposure, is consistent over time in cigarette smokers, supporting its use of tobacco smoke exposure, and 3-HPMA levels were less stable over time, this biomarker is nevertheless a useful monitor of human acrolein exposure.
Acrolein Exposure Is Associated With Increased Cardiovascular Disease Risk
TLDR
Regardless of its source, acrolein exposure is associated with platelet activation and suppression of circulating angiogenic cell levels, as well as increased CVD risk.
Cigarette smoking behaviour and blood metabolomics.
TLDR
These findings, with further validation in future studies, have implications regarding aetiology and study design of smoking-related diseases.
Urinary biomarkers of smokers’ exposure to tobacco smoke constituents in tobacco products assessment: a fit for purpose approach
  • E. Gregg, E. Minet, M. McEwan
  • Biology
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • 2013
TLDR
Additional requirements for the generation of robust data on urinary biomarkers, including toxicant metabolism and disposition, method validation and qualification for use in tobacco products comparison studies are discussed.
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4
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