Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity.

Abstract

Cyclophosphamide and ifosfamide are two commonly used DNA-alkylating agents in cancer chemotherapy that undergo biotransformation to several toxic and non-toxic metabolites, including acrolein and chloroacetaldehyde (CAA). Acrolein and CAA toxicities occur by several different mechanisms, including ROS formation and protein damage (oxidation), however… (More)
DOI: 10.1016/j.cbi.2012.11.017

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Cite this paper

@article{MacAllister2013AcroleinAC, title={Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity.}, author={Stephanie L MacAllister and Nicolas Martin-Brisac and Vincent Lau and Kai Yang and Peter James O'Brien}, journal={Chemico-biological interactions}, year={2013}, volume={202 1-3}, pages={259-66} }