Acrokeratosis verruciformis of Hopf showing P602L mutation in ATP2A2 and overlapping histopathological features with Darier disease.

@article{Bergman2012AcrokeratosisVO,
  title={Acrokeratosis verruciformis of Hopf showing P602L mutation in ATP2A2 and overlapping histopathological features with Darier disease.},
  author={Reuven Bergman and Tanya Sezin and Margarita Indelman and Wissam Abo Helou and Emily Avitan-Hersh},
  journal={The American Journal of dermatopathology},
  year={2012},
  volume={34 6},
  pages={597-601}
}
The relationship between acrokeratosis verruciformis (AKV) of Hopf and Darier disease (DD) has been debated for several decades. Both diseases are now thought to result from mutations in the same gene, that is, the ATP2A2 gene encoding the sarco (endo) plasmic reticulum Ca ATPase2 pump (SERCA2), although their histopathological features are different. We sought to detect possible overlapping histopathological features between AKV and DD. Fourteen members of a family affected by AKV were… CONTINUE READING