Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies.

@article{Bohane1977AcrodermatitisEZ,
  title={Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies.},
  author={Timothy D. Bohane and Ernest Cutz and J Richard Hamilton and Dietrich Gall},
  journal={Gastroenterology},
  year={1977},
  volume={73 3},
  pages={587-92}
}
An infant with acrodermatitis enteropathica was studied before and after starting zinc therapy. Clinical recovery was rapid, and the plasma zinc, serum and mucosal alkaline phosphatase activities returned to normal. Light microscopy of small intestinal biopsies showed normal mucosa. Electron microscopy of the Paneth cells initially revealed abnormal inclusion bodies which disappeared during therapy, suggesting that the abnormality is secondary to zinc deficiency, and not a primary defect. These… CONTINUE READING

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