Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum.

Abstract

By the newly developed assay method, the glycolipid Acremomannolipin A (1) was isolated from a filamentous fungus Acremonium strictum as a potential calcium signal modulator. The structure of 1 elucidated on the basis of intensive spectroscopic analyses as well as its degradation studies is quite unique: the d-mannopyranose is connected to d-mannitol through a β-glycoside linkage; all the hydroxyls in the mannose are highly masked as peresters with aliphatic acids, and this moiety is made hydrophobic, whereas the mannitol part exhibits a highly hydrophilic property. The compound (1) showed the characteristic bioactivity property, enabling calcineurin deletion cells to grow in the presence of Cl(-), which would be caused by calcium signal modulating. The activity was so potent as to exert the effect at a concentration of 200 nM.

DOI: 10.1016/j.bmcl.2012.08.085

Cite this paper

@article{Sugiura2012AcremomannolipinAT, title={Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum.}, author={Reiko Sugiura and Ayako Kita and Nozomi Tsutsui and Osamu Muraoka and Kanako Hagihara and Nanae Umeda and Tatsuki Kunoh and Hirofumi Takada and Dai Hirose}, journal={Bioorganic & medicinal chemistry letters}, year={2012}, volume={22 21}, pages={6735-9} }