Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with high intracellular concentrations of tenofovir diphosphate: a case report.

@article{Hoornenborg2017AcquisitionOW,
  title={Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with high intracellular concentrations of tenofovir diphosphate: a case report.},
  author={Elske Hoornenborg and Maria Prins and Roel C. A. Achterbergh and Lycke R. Woittiez and Marion Cornelissen and Suzanne Jurriaans and Neeltje A Kootstra and Peter L. Anderson and Peter Reiss and Henry J. C. de Vries and Jan C M Prins and Godelieve J de Bree},
  journal={The lancet. HIV},
  year={2017},
  volume={4 11},
  pages={e522-e528}
}
BACKGROUND Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consistent use of emtricitabine and tenofovir disoproxil fumarate. METHODS The patient… CONTINUE READING
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