Acquisition of resistance to apoptosis and necrosis by Bcl-xL over-expression in rat hepatoma McA-RH8994 cells.


BACKGROUND Bcl-xL is the predominant anti-apoptotic Bcl-2 family member in the liver. Suppression of cell death promotes carcinogenesis and contributes to resistance to radiation and chemotherapeutic agents. METHODS Direct effects of Bcl-xL protein on apoptosis and necrosis were investigated in rat hepatoma cells. Rat hepatoma cell line McA-RH8994 cells… (More)


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