Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma

@article{Uchida2004AcquisitionOL,
  title={Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma},
  author={Daisuke Uchida and Nasima-Mila Begum and Yoshifumi Tomizuka and Takashi Bando and Ammar Almofti and Hideo Yoshida and Mitsunobu Sato},
  journal={Laboratory Investigation},
  year={2004},
  volume={84},
  pages={1538-1546}
}
Recently, it has been suggested that chemokine/receptor interactions determine the destination of the invasive tumor cells in several types of cancer. It has also been proposed that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system might be involved lymph node metastasis in oral squamous cell carcinoma (SCC). In order to further clarify the role of the SDF-1/CXCR4 system in oral SCC, we generated CXCR4 stable transfectants (IH-CXCR4) using oral SCC cells, and compared them to IH… CONTINUE READING

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The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma

A Ammar, D Uchida, NM Begum
Int J Oncology • 2004

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