Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons.

  title={Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons.},
  author={Chang-Hwan Park and Jin Sun Kang and Yeon Ho Shin and M S Chang and Seungsoo Chung and H J Koh and Mei Zhu and Seog Bae Oh and Yong-Sung Lee and Georgia Panagiotakos and Vivian Tabar and Lorenz Studer and Sang-Hun Lee},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 14},
Neural precursor cells provide an expandable source of neurons and glia for basic and translational applications. However, little progress has been made in directing naive neural precursors toward specific neuronal fates such as midbrain dopamine (DA) neurons. We have recently demonstrated that transgenic expression of the nuclear orphan receptor Nurr1 is sufficient to drive dopaminergic differentiation of forebrain embryonic rat neural precursors in vitro. However, Nurr1-induced DA neurons… CONTINUE READING
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of ventral midbrain dopaminergic neurons

  • E. Andersson, J. B. Jensen, M. Parmar, F. Guillemot, A. Bjorklund
  • Development
  • 2006

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