Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense.

@article{Berthou1997AcquisitionOG,
  title={Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense.},
  author={Christian Berthou and L Michel and Annie Souli{\'e} and Francette Jean-Louis and B{\'e}atrice Flageul and Louis Dubertret and François Sigaux and Yan Zhang and Marilyne Sasportes},
  journal={Journal of immunology},
  year={1997},
  volume={159 11},
  pages={5293-300}
}
In vertebrate tissues, cell integrity is maintained by at least three mechanisms. During an immune response, injured cells are eliminated by cytotoxic lymphoid cells that produce perforin, granzyme B, and Fas ligand (FasL). Second, epithelial cells can produce FasL as an immunosuppressive protein, probably to protect the tissue against immune-mediated damage. Third, locally secreted antimicrobial peptides can be operative in the protection of animal and human epithelia. In this work, as another… CONTINUE READING

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