Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.

@article{Bateman2010AcquisitionOG,
  title={Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.},
  author={Caroline M. Bateman and Susan M. Colman and Tracy Chaplin and Bryan D. Young and Tim O B Eden and Manoo G Bhakta and Eric J Gratias and Elisabeth R van Wering and Giovanni Cazzaniga and Christine J Harrison and Richard D.W. Hain and Philip James Ancliff and Anthony M. Ford and Lyndal Kearney and Mel Greaves},
  journal={Blood},
  year={2010},
  volume={115 17},
  pages={3553-8}
}
Chimeric fusion genes are highly prevalent in childhood acute lymphoblastic leukemia (ALL) and are mostly prenatal, early genetic events in the evolutionary trajectory of this cancer. ETV6-RUNX1-positive ALL also has multiple ( approximately 6 per case) copy number alterations (CNAs) as revealed by genome-wide single-nucleotide polymorphism arrays… CONTINUE READING