Acquisition of competence to condense metaphase I chromosomes during spermatogenesis.

@article{Cobb1999AcquisitionOC,
  title={Acquisition of competence to condense metaphase I chromosomes during spermatogenesis.},
  author={Justin Cobb and Benjamin J. Cargile and Mary Ann Handel},
  journal={Developmental biology},
  year={1999},
  volume={205 1},
  pages={
          49-64
        }
}
Little is known about the timing of meiotic prophase events during spermatogenesis in the mouse or how these events are related to cell-cycle progression. This work was designed to test hypotheses about the timing and biochemical correlates of developmental acquisition of competence to condense bivalent pairs of homologous chromosomes held together by chiasmata. The experimental approach takes advantage of the fact that okadaic acid (OA) treatment of pachytene spermatocytes causes precocious… CONTINUE READING
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