Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression.

@article{Qu2006AcquisitionOA,
  title={Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression.},
  author={Wei Qu and Richard Fuquay and Teruaki Sakurai and Michael P. Waalkes},
  journal={Molecular carcinogenesis},
  year={2006},
  volume={45 8},
  pages={561-71}
}
Prior work has shown that chronic cadmium exposed rat liver epithelial cells (CCE-LE) become malignantly transformed after protracted low level cadmium exposure. Acquisition of apoptotic resistance is common in oncogenesis and the present work explores this possibility in CCE-LE cells. CCE-LE cells were resistant to apoptosis induced by etoposide or an… CONTINUE READING