Acquisition of a determinant for chloramphenicol resistance by coliphage lambda.

@article{Gottesman1975AcquisitionOA,
  title={Acquisition of a determinant for chloramphenicol resistance by coliphage lambda.},
  author={Michael M. Gottesman and Judah L. Rosner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1975},
  volume={72 12},
  pages={5041-5}
}
A determinanat for chloramphenicol resistance, cam, initially detected on a resistance transfer factor (RTF) and since transferred to phage P1, may be acquired from P1 by coliphage lambda. Lambdapcam are obtained when a lambda prophage is induced in bacteria which also harbor P1 cam prophage. Lambdacam formation is not dependent upon host Rec or lambda Red recombination functions. Electron microscopic heteroduplex analysis shows that the cam locus in two lambdapcams is a 5% addition of DNA in… CONTINUE READING

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