Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sjögren Patients

@inproceedings{Visser2018AcquisitionON,
  title={Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sj{\"o}gren Patients},
  author={Annie Visser and Marieke E. Doorenspleet and Niek de Vries and Frederik K. L. Spijkervet and A Vissink and Richard J. Bende and Hendrika Bootsma and Frans G. M. Kroese and Nicolaas A. Bos},
  booktitle={Front. Immunol.},
  year={2018}
}
Previous studies revealed high incidence of acquired N-glycosylation sites acquired N-glycosylation sites in RNA transcripts encoding immunoglobulin heavy variable region (IGHV) 3 genes from parotid glands of primary Sjögren's syndrome (pSS) patients. In this study, next generation sequencing was used to study the extent of ac-Nglycs among clonally expanded cells from all IGVH families in the salivary glands of pSS patients. RNA was isolated from parotid gland biopsies of five pSS patients and… CONTINUE READING