Acquisition of MDMA self-administration: pharmacokinetic factors and MDMA-induced serotonin release.

  title={Acquisition of MDMA self-administration: pharmacokinetic factors and MDMA-induced serotonin release.},
  author={Sarah Bradbury and Judith Bird and Joyce Colussi-Mas and Melanie Mueller and George A. Ricaurte and Susan Schenk},
  journal={Addiction biology},
  volume={19 5},
The current study aimed to elucidate the role of pharmacokinetic (PK) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4-methylenedioxymethamphetamine (MDMA) self-administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of 1.0 mg/kg MDMA (iv) prior to, and following, the acquisition of MDMA self-administration. Synaptic levels of 5-hydroxytryptamine (5HT) and dopamine (DA) in the nucleus accumbens were measured… CONTINUE READING
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