Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

@inproceedings{Watanabe2011AcquisitionOH,
  title={Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt},
  author={Yohei Watanabe and Madiha Salah Ibrahim and Hany F. Ellakany and Norihito Kawashita and Rika Mizuike and Hiroaki Hiramatsu and Nogluk Sriwilaijaroen and Tatsuya Takagi and Yasuo Suzuki and Kazuyoshi Ikuta},
  booktitle={PLoS pathogens},
  year={2011}
}
Highly pathogenic avian influenza A virus subtype H5N1 is currently widespread in Asia, Europe, and Africa, with 60% mortality in humans. In particular, since 2009 Egypt has unexpectedly had the highest number of human cases of H5N1 virus infection, with more than 50% of the cases worldwide, but the basis for this high incidence has not been elucidated. A change in receptor binding affinity of the viral hemagglutinin (HA) from α2,3- to α2,6-linked sialic acid (SA) is thought to be necessary for… CONTINUE READING
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