Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa.

@article{Yokoyama2003AcquisitionO1,
  title={Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa.},
  author={Keiko Yokoyama and Yohei Doi and Kunikazu Yamane and Hiroshi Kurokawa and Naohiro Shibata and Keigo Shibayama and Tetsuya Yagi and Haru Kato and Yoshichika Arakawa},
  journal={Lancet},
  year={2003},
  volume={362 9399},
  pages={1888-93}
}
BACKGROUND Bacteria develop resistance to aminoglycosides by producing aminoglycoside-modifying enzymes such as acetyltransferase, phosphorylase, and adenyltransferase. These enzymes, however, cannot confer consistent resistance to various aminoglycosides because of their substrate specificity. Notwithstanding, a Pseudomonas aeruginosa strain AR-2 showing high-level resistance (minimum inhibitory concentration >1024 mg/L) to various aminoglycosides was isolated clinically. We aimed to clone and… CONTINUE READING
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