Acquiring signalling specificity from the cytokine receptor gp130.

  title={Acquiring signalling specificity from the cytokine receptor gp130.},
  author={Matthias Ernst and Brendan J Jenkins},
  journal={Trends in genetics : TIG},
  volume={20 1},
Repeated use of a relatively small number of intracellular signalling molecules specifies tissue- and cell-type-specific responses to pleiotropic-acting growth factors and cytokines. Currently, gaining a better understanding of these mechanisms is a major challenge. The IL-6 family of cytokines shares a common receptor subunit called gp130. Phenotypic comparisons of mice with amino acid knock-in substitutions that disable individual signalling modules in gp130, with knockout mice lacking ligand… CONTINUE READING

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