Acquirement of Brown Fat Cell Features by Human White Adipocytes*

@article{Tiraby2003AcquirementOB,
  title={Acquirement of Brown Fat Cell Features by Human White Adipocytes*},
  author={Claire Tiraby and Genevi{\`e}ve Tavernier and Corinne Lefort and Dominique Larrouy and Fr{\'e}d{\'e}ric Bouillaud and Daniel Ricquier and Dominique Langin},
  journal={Journal of Biological Chemistry},
  year={2003},
  volume={278},
  pages={33370 - 33376}
}
Obesity, i.e. an excess of white adipose tissue (WAT), predisposes to the development of type 2 diabetes and cardiovascular disease. Brown adipose tissue is present in rodents but not in adult humans. It expresses uncoupling protein 1 (UCP1) that allows dissipation of energy as heat. Peroxisome proliferator-activated receptor γ (PPARγ) and PPARγ coactivator 1α (PGC-1α) activate mouse UCP1 gene transcription. We show here that human PGC-1α induced the activation of the human UCP1 promoter by… 

Figures and Tables from this paper

Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes.
Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells
TLDR
It is indicated that atrophy of BAT causes transformation into white adipocyte-like cells in the adult mouse and also suggests that further molecular understanding of adipocyte plasticity using the authors' transgenic mouse model might be beneficial for the development of anti-obesity/anti-diabetic therapies.
Research Progress of Key Factors for the Transformation of Adipose Tissue
TLDR
The key factors of transformation of adipose tissue were studied, and some prospects for the study of the fat tissue transformation of small mammals were given.
Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis*
TLDR
It is demonstrated that the mRNA and protein expression of Ubc9 are regulated by the microRNA miRNA-30a (miR-30A) in human subcutaneous adipocytes, demonstrating a previously unappreciated molecular axis that controls browning of human white adipocytes.
Brown fat biology and thermogenesis.
TLDR
This review aims at the unique biology of BAT with the emphasis put on the recent discoveries regarding the brown adipocyte development and function.
Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes.
TLDR
A high-throughput microscopy screen identified ubiquitin carrier protein 9 (Ubc9) as a negative regulator of energy storage in human sc adipocytes and demonstrated a critical role for Ubc9 in the regulation of sc adipocyte energy homeostasis.
Remodeling of white adipose tissue after retinoic acid administration in mice.
TLDR
Results indicate that ATRA favors the acquisition of brown adipose tissue-like properties in WAT, which can contribute to new avenues of prevention and treatment of obesity and type 2 diabetes.
Farnesol Has an Anti-obesity Effect in High-Fat Diet-Induced Obese Mice and Induces the Development of Beige Adipocytes in Human Adipose Tissue Derived-Mesenchymal Stem Cells
TLDR
Farnesol could be a potential therapeutic agent for obesity treatment by inhibiting adipogenesis and the related key regulators and inducing the development of beige adipocytes in both inguinal and epididymal WAT.
...
...

References

SHOWING 1-10 OF 56 REFERENCES
Activation of the Nuclear Receptor Peroxisome Proliferator-activated Receptor γ Promotes Brown Adipocyte Differentiation*
TLDR
It is suggested that PPARγ functions not only in the storage of excess energy in white adipose tissue but also in its dissipation in BAT, which is a key regulatory factor in brown adipocytes.
Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization.
TLDR
The results demonstrate that adipocytes expressing UCP are present in adipose deposits considered as white fat, and suggest the existence of a continuum in rodents between BAT and WAT, and a great plasticity between adipose tissue phenotypes.
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.
TLDR
Transgenic mice that overexpress nSREBP-1c in adipose tissue under the control of the adipocyte-specific aP2 enhancer/promoter exhibit many of the features of congenital generalized lipodystrophy (CGL), an autosomal recessive disorder in humans.
Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.
TLDR
It is proposed that the effects of PPARalpha activation on expression of the brown fat-specific uncoupling protein-1 (ucp-1) gene mediates ucp-1 gene up-regulation associated with adipogenic differentiation or in coordination with gene expression for the fatty acid oxidation machinery required for active thermogenesis.
Functional assessment of white and brown adipocyte development and energy metabolism in cell culture. Dissociation of terminal differentiation and thermogenesis in brown adipocytes.
TLDR
Results imply a possible dissociation of terminal differentiation and thermogenic function of brown adipocytes.
Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma
TLDR
The results show that PPAR gamma is a regulator of the differentiation-dependent expression of UCP and suggest that there are additional factors in HIB-1B cells required for brown adipocyte-specific UCP expression.
The human uncoupling protein‐1 gene (UCP1): present status and perspectives in obesity research
TLDR
Understanding the mechanisms which regulate transcription and expression of the human UCP1 gene will facilitate the identification of molecules able to increase the levels of this protein in order to modulate energy expenditure in adult humans.
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.
TLDR
The results suggest that UCP synthesized from the aP2 gene promoter is thermogenically active and capable of reducing fat stores.
Convertible adipose tissue in mice
TLDR
Ability to express uncoupling protein (UCP) and establish UCP-dependent thermogenesis was analyzed in anatomical areas of mice and described changes showed that besides typical brown and white adipose tissue in mice, there existed a third type of adipOSE tissue described as convertible adiposes tissue.
...
...