Acquired von Willebrand syndromes: clinical features, aetiology, pathophysiology, classification and management.

@article{Michiels2001AcquiredVW,
  title={Acquired von Willebrand syndromes: clinical features, aetiology, pathophysiology, classification and management.},
  author={Jan Jacques Michiels and Ulrich Budde and Marc G Van der Planken and Huub H D M van Vliet and Wilfried Schroyens and Zwi Nisan Berneman},
  journal={Best practice & research. Clinical haematology},
  year={2001},
  volume={14 2},
  pages={401-36}
}
Acquired von Willebrand syndrome (AVWS) associated with hypothyroidism is of type I, results from a decreased synthesis of factor VIII and von Willebrand factor (VWF), responds to desmopressin with normal half-life times for factor VIII and VWF parameters, and disappears after treatment with I-thyroxine. AVWS type I or III, which occurs in a minority of patients with Wilms' tumour in the complete absence of an inhibitor against VWF and no absorption of factor VIII or VWF onto nephroblastoma… CONTINUE READING

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