Acquired von Willebrand syndrome in aortic stenosis.

@article{Vincentelli2003AcquiredVW,
  title={Acquired von Willebrand syndrome in aortic stenosis.},
  author={Andr{\'e} Vincentelli and Sophie Susen and Thierry Le Tourneau and Isabelle Six and Olivier Fabre and Francis Juthier and Anne Bauters and Christophe Decoene and Jenny Goudemand and Alain Prat and Brigitte Jude},
  journal={The New England journal of medicine},
  year={2003},
  volume={349 4},
  pages={
          343-9
        }
}
BACKGROUND Aortic-valve stenosis can be complicated by bleeding that is associated with acquired type 2A von Willebrand syndrome. However, the prevalence and cause of the hemostatic abnormality in aortic stenosis are unknown. METHODS We enrolled 50 consecutive patients with aortic stenosis, who completed a standardized screening questionnaire to detect a history of bleeding. Forty-two patients with severe aortic stenosis underwent valve replacement. Platelet function under conditions of high… Expand
Acquired and reversible von Willebrand disease with high shear stress aortic valve stenosis.
BACKGROUND Severe aortic valve stenosis is relatively more prevalent in patients with repeated bleeding episodes. The goal of the present study was to determine the effect of aortic valve replacementExpand
Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation.
TLDR
The present case of a patient with endocarditis-associated severe aortic Regurgitation and mitral regurgitation exhibited a clinically significant bleeding diathesis secondary to AVWS, which was successfully treated with perioperative supplementation of VWF and factor VIII. Expand
Acquired von Willebrand syndrome in children with aorticand pulmonary stenosis
TLDR
AVWS is not rare in stenotic obstructive cardiac diseases, but a detailed history of bleeding should be taken from patients with valvular disease, and whole blood count, PT and aPTT should be performed. Expand
von Willebrand factor abnormalities in aortic valve stenosis: Pathophysiology and impact on bleeding.
TLDR
VWF abnormalities did not exacerbate peri-operative blood loss, however - a finding consistent with the full correction of these VWF abnormalities, seen already on the first postoperative day and persisting for up to six months after surgery. Expand
Treatment of acquired von Willebrand syndrome in aortic stenosis with transcatheter aortic valve replacement.
TLDR
Investigating the prevalence of abnormal von Willebrand multimers (AbM) in patients undergoing transcatheter aortic valve replacement (TAVR) and the impact of TAVR on the underlying factor variances concluded that T AVR is capable of correcting AbM and therefore possibly aVWS in patients with AS. Expand
Impairment of platelet retention rate in patients with severe aortic valve stenosis.
TLDR
These findings suggest that impairment of platelet retention rate is seen in almost all patients with severe AS and Clinicians should be aware of the possibilities of vWF-mediated platelet dysfunction and bleeding tendency in patients withsevere AS. Expand
Von Willebrand factor in aortic or mitral valve stenosis and bleeding after heart valve surgery.
TLDR
In severe AS, VWF levels and activity correlate inversely with transvalvular pressure gradients, and are lower than in severe degenerative MS, but do not affect blood loss after valvular surgery in extracorporeal circulation. Expand
Transcatheter aortic valve implantation in a patient with suspected hereditary von Willebrand disease and severe gastrointestinal bleeding – a case report
TLDR
AVWS should be considered in patients with suspected inherited von Willebrand disease and concomitant severe aortic valve stenosis, since it constitutes a treatable cause of a potentially severe bleeding disorder. Expand
Aortic stenosis, von Willebrand factor, and bleeding.
  • J. Sadler
  • Medicine
  • The New England journal of medicine
  • 2003
TLDR
This question about the prevalence of symptomatic defects in von Willebrand factor in patients with aortic stenosis is addressed and new information about the response of such hemostatic abnormalities to valve replacement is provided. Expand
Hypertrophic obstructive cardiomyopathy, acquired von Willebrand syndrome, and gastrointestinal bleeding.
TLDR
The report by Blackshear et al provides valuable validation of existing theories linking blood flow conditions of high shear stress (ie, increased velocity between adjacent layers of blood flowing within the vasculature) to AvWS and implies a potential, or at least a partial, causal relationship between acquired vWF abnormalities and GI hemorrhage in this group of patients. Expand
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