Acquired von Willebrand's syndrome resulting from untreated hypothyroidism in two prepubertal girls.

@article{GalliTsinopoulou2006AcquiredVW,
  title={Acquired von Willebrand's syndrome resulting from untreated hypothyroidism in two prepubertal girls.},
  author={Assimina Galli-Tsinopoulou and Charilaos Stylianou and Georgios Papaioannou and Sanda Nousia-Arvanitakis},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2006},
  volume={12 6},
  pages={687-9}
}
Acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder associated with a number of different diseases, including hypothyroidism. We describe two prepubertal girls with AvWS and undiagnosed hypothyroidism due to thyroiditis Hashimoto. The patients had neither family history nor symptoms of bleeding disorders. Substitution therapy with levothyroxine led to normalization of the coagulation parameters. We report these cases in order to raise awareness among paediatricians so that the… CONTINUE READING